Liver Biome+ · 1,200+ studies
Liposomal Milk Thistle (Silymarin)
A flavonolignan complex from milk thistle seed (Silybum marianum), of which silybin is the main active. It is one of the longest-studied hepatoprotective botanicals in the literature.
The form we use
Liposomal silymarin, 350 mg equivalent
Silymarin's known limitation is poor aqueous solubility and low oral bioavailability — the reason phospholipid-complexed silybin was developed and studied pharmacokinetically in the first place. TruWe uses a liposomal (phospholipid) carrier for exactly that reason, standardised to a 350 mg silymarin equivalent so the dose is comparable to the literature.
Why this form
How the common forms compare
| Form | What published literature reports | In TruWe |
|---|---|---|
| Plain milk thistle powder | Whole-herb material; silymarin content varies and solubility is low. | Not used |
| Standardised silymarin extract | Defined active content, but the solubility limitation remains. | Not used |
| Phospholipid-complexed / liposomal silymarin | The delivery approach developed and pharmacokinetically studied to address silymarin's poor solubility. | Used |
Dose
Where it appears, and how much
Liver Biome+
350 mg Eq
silymarin equivalent, liposomal
View product →
The evidence
What the research says
Liposomal silymarin (350 mg equivalent) — helps stabilise hepatocyte membranes and supports bile flow and hepatic resilience.
Reference researcher: Prof. Rolf Gebhardt · University of Leipzig
- Milk thistle in liver diseases: past, present, future
Phytotherapy Research · 2010
- Silybin and the liver: from basic research to clinical practice
World Journal of Gastroenterology · 2011
- A phase I and pharmacokinetic study of silybin-phytosome
Investigational New Drugs · 2007
Questions, answered
Liposomal Milk Thistle (Silymarin) FAQ
- What does '350 mg Eq' mean?
- The dose is expressed as its silymarin equivalent, so it can be compared directly with doses used in published studies rather than to raw herb weight.
- Is milk thistle the same as silymarin?
- Silymarin is the active flavonolignan complex extracted from milk thistle seed. Plain milk thistle powder is the raw material.
- Why liposomal here but not for NAC?
- Silymarin is poorly water-soluble, which is the documented reason phospholipid delivery was developed for it. NAC does not have that problem.
- Can I take it long term?
- Milk thistle has a long use history, but if you have a diagnosed liver condition or take medication, run it past your doctor first.
Ingredient-level research is published on the individual actives and their delivery forms. It describes the ingredients, not a finished-product claim. These statements have not been evaluated by the FSSAI or FDA. This content is for information only and is not medical advice.
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