Ova Balance · 400+ studies
D-Chiro Inositol
The second inositol stereoisomer, made in the body from myo-inositol by an insulin-dependent enzyme. It was the subject of the original New England Journal of Medicine PCOS work in 1999.
The form we use
D-chiro inositol, dosed at 50 mg to hold the 40:1 ratio with myo-inositol
D-chiro inositol matters because of proportion, not quantity. The literature describes reduced ovarian benefit when D-chiro exposure is disproportionately high, so the dose is fixed at 50 mg against 2000 mg myo-inositol to hold the physiological ratio rather than maximised for a bigger number on the label.
Why this form
How the common forms compare
| Form | What published literature reports | In TruWe |
|---|---|---|
| D-chiro inositol alone | Studied historically, but modern practice pairs it with myo-inositol. | Not used |
| 50 mg D-chiro with 2000 mg myo (40:1) | Holds the plasma ratio used in current inositol trials. | Used |
| High-dose D-chiro | Literature discusses diminishing ovarian benefit at disproportionate D-chiro exposure. | Not used |
Dose
Where it appears, and how much
Ova Balance
50 mg
40:1 with myo-inositol
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The evidence
What the research says
The original PCOS breakthrough — improves insulin sensitivity, androgen balance and ovulation when paired with myo-inositol in the 40:1 ratio.
Reference researcher: Prof. John E. Nestler · Virginia Commonwealth University
- Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome
New England Journal of Medicine · 1999
- Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome
Gynecological Endocrinology · 2017
- Randomized, double-blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in PCOS
European Review for Medical & Pharmacological Sciences · 2007
Questions, answered
D-Chiro Inositol FAQ
- Why so little D-chiro inositol?
- Because the ratio is the point. More is not better here — the 40:1 proportion is what the current literature is built on.
- Isn't D-chiro the one from the famous PCOS study?
- Yes, the 1999 NEJM trial used D-chiro inositol. Later work moved to the combined 40:1 approach.
- Do I need to take them separately?
- No — both are pre-dosed in a single Ova Balance sachet.
- Is it the same as inositol from food?
- Food inositol is overwhelmingly myo-inositol. D-chiro is normally produced in the body from it.
Ingredient-level research is published on the individual actives and their delivery forms. It describes the ingredients, not a finished-product claim. These statements have not been evaluated by the FSSAI or FDA. This content is for information only and is not medical advice.
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